Two sample MR report
PKIB_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | -0.1287703 | 0.0671253 | 0.0913465 |
| Weighted median | 10 | 0.0166188 | 0.0080211 | 0.0382750 |
| Inverse variance weighted | 10 | 0.0163613 | 0.0060754 | 0.0070803 |
| Simple mode | 10 | 0.0182546 | 0.0135359 | 0.2104163 |
| Weighted mode | 10 | 0.0127657 | 0.0127000 | 0.3410704 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.6054751 | 8 | 0.9997249 |
| Inverse variance weighted | 5.3187698 | 9 | 0.8056822 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1041633 | 0.0479791 | 0.0617211 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000158 | 0 | TRUE | 0.2333072 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
